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One of these is nicotine

Elevated homocysteine levels are associated with an increased risk of heart-related issues, making B12 a crucial element in cardiovascular health maintenance

Hyperreactivity or asthma attacks are frequently the cause of death for people with asthma due to oxygen deprivation and respiratory distress from mucus obstruction (Yoshida et al., 2020)

Mild reactions may resolve by discontinuing supplements, while severe symptoms may require medical intervention, such as supportive care or medication

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Neuron 96 , 12 (2017)