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Availability and practical considerations An important distinction is regulatory status
This research provides additional evidence to suggest that discontinuing GLP-1 agonists at least 14 days before total joint replacement surgery is optimal to reduce the risk of delayed emergence from anesthesia, aspiration events, aspiration pneumonitis ,and conversion to intubation, said study author John R
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Bertilsson et al
The goal was to create medications that mimicked the beneficial metabolic effects of GLP-1 while maintaining stability in the human body long enough to provide practical clinical utility
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