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When to contact your provider: While mild reactions are expected, some symptoms warrant a call to your healthcare provider: Redness, swelling, or pain that spreads or worsens over several days Signs of infection, like warmth, pus, or fever Severe itching or rash beyond the injection site When a reaction is an emergency: If you have any signs of allergic reaction, like difficulty breathing, swelling of the face or throat, or rapid heartbeat, call 911 and get immediate medical attention

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doi: 10.1038/s41467-023-38444-2 165 LiXSObeidSKlingenbergRGencerBMachFRberLet al