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Current US prescribing information lists personal or family history of medullary thyroid carcinoma (MTC), MEN 2, and previous serious hypersensitivity to tirzepatide or its ingredients as strict contraindications
This network meta-analysis studied the effects of different antioxidants on the sperm quality and pregnancy rate of idiopathic male infertility
The SELECT trial showed that semaglutide 2.4 mg (Wegovy) reduces cardiovascular risk in adults with established cardiovascular disease and either overweight or obesity, leading to an FDA-approved indication for reducing cardiovascular risk in this population
If the concern is overall body weight alongside visceral fat, a broader metabolic peptide may deliver more total benefit