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UV light can degrade the benzyl alcohol preservative

The timeline depends heavily on baseline NNMT activity, metabolic health, and consistency of use

However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food

If your provider thinks it is safe, they will teach you proper technique, needle disposal, and how to watch for side effects

Mills et al

Dietary sources of B12, such as meat, fish, and dairy products, provide most people with enough of the vitamin