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Description

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Research examining human cardiac samples has revealed several key findings: GLP-1R mRNA transcripts have been consistently detected in all four cardiac chambers from human hearts, at levels approximating those in human pancreas [1] Receptor expression is notably absent in cardiac fibroblasts, coronary artery endothelial cells, and vascular smooth muscle cells according to some studies [1] Human GLP-1R expression appears predominantly in cardiomyocytes, albeit at relatively low levels [2] Interestingly, species differences exist in GLP-1R distribution patterns

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Treatment risks included weight gain (none, 5%, 10%), added risk of skin rash (none, 10%, 20%), and risk of liver damage (none, 1 in 1000, 10 in 1000)

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[8] [9] The net effect of combining these agents on glycaemic control is unpredictable and could result in dysglycaemia particularly hyperglycaemia or worsening insulin resistance especially in individuals with pre-existing impaired glucose tolerance or type 2 diabetes

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Common side effects associated with nootropics include: Headaches Nausea Insomnia Anxiety Increased heart rate and blood pressure Additionally, some nootropics can interact with other medications, such as blood thinners, and may not be suitable for individuals with certain medical conditions, including high blood pressure or glaucoma

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