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Deoxycholic acid-induced gut dysbiosis disrupts bile acid enterohepatic circulation and promotes intestinal inflammation
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Native IGF-1's extremely short free half-life of 12-15 minutes is primarily determined by rapid IGFBP capture (which removes it from the free pool), renal filtration of the small 7.6 kDa protein, and IGF-1R-mediated endocytosis and lysosomal degradation
BMC gastroenterology , 17 (1), 96