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Yes, especially when combined with exercise and calorie control

There are clear situations where it makes more sense than tirzepatide, and dismissing it entirely because tirzepatide produces more weight loss would be a mistake

For immunostainings cells were blocked for 30 min in blocking buffer (10% GS, 0.3% Triton-X-100, 20 mM HEPES pH 7.4), then incubated with anti-p62 antibody (1:200, BD Bioscience, 610832), washed three times for 10 min in PBS, incubated with AF568-labeled goat-anti-mouse antibody, washed again three times in PBS for 10 min, and finally mounted using Shandon TM Immu-Mount TM containing Hoechst33342

doi: 10.1089/bio.2018.0039 49 ShirzeyliMHEiniFShirzeyliFHMajdSAGhahremaniMJoupariMDet al

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Compared to constructs without IGF-1 overexpression, IGF-1-overexpressing constructs significantly promoted osteochondral repair and reduced cartilage degeneration near the defect