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279,318 c-Jun N-terminal kinase (JNK) is a mitogen-activated protein kinase (MAPK) involved in regulating cellular stress responses and inflammation

Applying patches to skin that is damp, oily, or covered with lotion creates a barrier that prevents proper contact and may lead to premature detachment or inconsistent medication delivery

The Lancet and Nature Communications data suggest this is a real pharmacological effect rather than a reporting artifact

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