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High-dose niacin supplements should be avoided, as they can impair insulin sensitivity and raise glucose levels, potentially counteracting the benefits of tirzepatide

The condition can manifest as small, itchy bumps that may become crusty if scratched

Prescribing purely for obesity without a psychiatric indication may be viewed as outside your scope of practice

Collagen supplementation may help preserve skin elasticity and firmness during weight loss, though it cannot fully prevent loose skin in all cases

Brian Hortz, PhD, AT just published a deep-dive on the mechanisms and why they matter

"Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt"