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Weight loss plateaus result from metabolic adaptation (decreased basal metabolic rate), hormonal counter-regulation (reduced leptin and increased ghrelin), and shifts in body composition from rapid initial water loss to slower fat mass reduction

These studies have also shown similar effectiveness to the medication glibenclamide

BMA (UK)

Counsel patients regarding the potential risk for MTC with the use of RYBELSUS and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness)

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Good for mid-range doses (1mg4mg)