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doi: 10.1038/s41591-023-02597-w 106 AronneLJSattarNHornDBBaysHEWhartonSLinW-Yet al

For the average female, E 2 varies from 0.135 to [24,25]

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It also notes that hot flashes and sleep disruption during menopause may interact with the medication's systemic effects, calling for closer monitoring of overall symptom burden with a provider