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Vitamin B12 is necessary for healthy nerve function, and deficiency of the vitamin can lead to neuropathy

Measurements using body composition methods (DEXA, bioimpedance, caliper) are more informative than scale weight alone, as AOD-9604 may preserve lean tissue while selectively reducing fat mass

in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

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MOTS-c targets energy substrate utilization at the mitochondrial level

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