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Considering the severe ischemic lesions noted in the controls and an apparent similarity between ischemic disorders in rats and humans, a favorable application of NaBPC157 for treating brain ischemic disorders in humans is apparent

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Kynurenine is subsequently converted to NAD + in a chain of reactions with the rate-limiting step by quinolinic phosphoribosyltransferase (QPRT), which converts quinolinic acid into nicotinic acid mononucleotide (NAMN) 26 , finally entering the PreissHandler pathway