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Diabetes Care 2019;42:22722281 [DOI] [PubMed] [Google Scholar] 56

This is as a result of improved endothelial function, the inner layer of blood vessels, which has a direct effect on nitric oxide levels which dilate blood vessels, improving blood flow

In some individuals, particularly those following a low-carbohydrate diet or experiencing intercurrent illness, the body may produce ketones as it metabolises fat for energy

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What the STEP 4 data makes clear is that weight regain is a real possibility after stopping the medication, which is why a long-term maintenance strategy matters

52 Although the mechanisms underlying the sex- and compartment-specific skeletal effects of CR remain incompletely defined, several plausible explanations can be advanced