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the compound's evidence base is limited to preclinical in vitro and animal (largely rodent) studies of IGF-1 receptor activation, muscle-cell signaling, and tissue repair, with human safety and efficacy data for this specific analog effectively absent

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doi:10.1038/19539 Acknowledgments This study was supported by a grant (A050432) from the Korea Health 21 R&D Project, Ministry of Health and Welfare

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Store in a cool, dry place after opening.

181,182 In the apoptosis pathway, Fas ligation changes its conformational structure, allowing signaling molecules (i.e., FADD, cFLIP, and procaspase-8) to bind to the intracellular C-terminal signaling death domain of the receptor