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Secondary objectives included comparing the effects of semaglutide 2.4 mg to placebo with regards to mortality, cardiovascular risk factors, glucose metabolism, body weight and renal function

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The SUMMIT data suggest that, if approved, tirzepatide could provide a significant advancement for these patients, potentially setting a new standard of care. The overall safety profile of tirzepatide in the SUMMIT trial was consistent with previously reported tirzepatide studies

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Serum metabolomics of end-stage renal disease patients with depression: potential biomarkers for diagnosis