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Animal models of muscle crush injury and tendon damage have consistently shown faster functional recovery, improved tissue architecture, and reduced scar formation when TB-500 is administered shortly after the injury

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Blocking NNMT activity has been shown in research settings to influence body composition, leading to reduced adipocyte size, alterations in fat mass, and measurable changes in plasma biomarkers such as glucose and cholesterol

On either side of the vermis is a region called the paravermis, which is not structurally distinct, but does contain dedicated circuits for executing specific behaviors