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While large-scale clinical trials are still limited, the existing data is encouraging

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134,135 The endoplasmic reticulum-resident stimulator of interferon genes (STING) is activated by the cGAMP molecule and then moves to the Golgi to form a complex with IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1)

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This selection also ensured sufficiently large sample sizes for robust disease-disease association analyses, while minimizing biases from platform heterogeneity