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[DOI] [PubMed] [Google Scholar] 159.Ghaemian A, Salehifar E, Jalalian R, Ghasemi F, Azizi S, Masoumi S, Shiraj H, Mohammadpour RA, Bagheri GA

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This architecture creates an extraordinarily high binding affinity (pK = 16.44), roughly 10 million times stronger than other tripeptides and comparable to albumins copper binding

Furthermore, using a murine cholangitis model, the researchers clarified the underlying mechanisms: butyrate activates peroxisome proliferator-activated receptor delta (PPARD) to promote fatty acid -oxidation (FAO)-mediated metabolic reprogramming