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In mouse embryonic stem cells, dopamine, the D1-like agonist SKF-38393, and the D2-like agonist quinpirole activated all three members of the MAPK family (Lee et al., 2006)

McGinnis JL, Dunkle JA, Cate JH, Weeks KM (2012) The mechanisms of RNA SHAPE chemistry

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We dont yet know how many times you can reset the age of a complex tissue like the eye, but I dont see any theoretical reason why we couldnt do it many, many times

Astrocytic transcriptomes and molecular signatures in various neurological diseases are highly diverse, again highlighting the heterogeneity of this process