It was found that the maximal mean weight loss relative to placebo was -3.06, -6.15, -7.45, and -5.5kg after 1 year with mean weight regain +0.48kg, +0.91kg, +1.27kg, +0.43kg the following year, respectively
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This physiological change may lead to retrograde flow of gastric contents into the esophagus, manifesting as heartburn, regurgitation, or other reflux symptoms
doi:10.1111/dom.13912
There was a slight reduction in FPG in Japanese subjects receiving semaglutide 0.5 and 1.0 mg, compared with placebo and in Caucasian subjects receiving semaglutide 1.0 mg (Supplementary Table S2)
95% CI, 0.46-1.91