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It is approved to improve glycemic control and reduce cardiovascular risk in adults with type 2 diabetes, often added when lifestyle measures and first-line oral medications are not enough

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M., Prins, J

Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

Berberine, on the other hand, is known to cause cramping, gas, and diarrhea in many users