glp-1 and mood glp 1 changes Long-term Success of GLP-1s Hinges on More Than Just a Prescription RAVE “GLP-1 Metabolic” Mood Energy

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These results suggest there is no excess cardiovascular risk with tirzepatide and are consistent with the improvements of numerous surrogate markers of cardiovascular health, including weight reduction, glycemic control with less hypoglycemia, blood pressure reduction, and improvements in the lipid profile

The longer GLP1 stays active, the stronger the appetite suppression and GI slowing, so you feel fuller faster and longer, reducing food and therefore calorie intake

The future of GLP-1RA therapy is promising

Binding to this allosteric site can still influence the sensitivity and activity of the receptor, but could lead to drugs with fewer off-target side-effects, since GLP-1 is involved in many different metabolic signalling pathways

Across all studies, the safety profile was consistent with the broader GLP-1 class: nausea, diarrhea, and mild gastrointestinal symptoms were the most common side effects, typically occurring during the dose escalation phase