Advances in omics technologies have enabled researchers to investigate the components and mechanisms of traditional Chinese medicine (TCM) with greater depth and systematic precision
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One such condition caused by Cymbalta, though rare, is serotonin syndrome, which occurs when the drug forces the body to build up abnormally high levels of serotonin
Specifically, under the stimulation of DNA damage, p53 is activated and its target genes p21 Waf1/Cip1 and Bax-1 are inhibited, and suppression of p21 Waf1/Cip1 towards cyclin-CDK and proliferating cellular nuclear antigen (PCNA) is diminished, thereby activating the cell cycle
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However, this is typically mild and will wear off quickly
