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The copper-binding ability of GHK is one of the reasons the peptide has become so heavily researched in dermatology and regenerative biology

As a synthetic fragment of human GH residues 176-191, it allows researchers to study the metabolic arm of GH signalling independently of IGF-1 pathway activation

For reconstituted peptides, freeze-thaw damage is particularly severe

Most considerations of non-animal alternatives for skin irritation/sensitization testing tend to examine a single aspect of the process (e.g., chemical reactivity, epidermal bioavailability, dendritic cell responses)

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