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Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes

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Good long-term plans also include patient education on sticking to the treatment and possibly needing it for life

These observations reinforce the need for well-designed randomised controlled trials (RCTs) to validate the findings and expand the evidence base

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action