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Common risk factors include: Pregnancy Dehydration Electrolyte imbalance Muscle fatigue Thyroid conditions Kidney disease or kidney failure Diabetic nerve damage Mineral deficiencies, including magnesium, potassium (hypokalemia), and calcium Chronic obstructive pulmonary disease (COPD) Peripheral artery disease (vascular disease) Neurological disorders (like Parkinsons disease or peripheral neuropathy) Liver cirrhosis Side effects of certain medications Determining the cause of your muscle spasms is the first step in the treatment of nocturnal leg cramps

Hooijmans, C

Note that trial durations differ and head-to-head comparisons are not yet available

If plaintiffs have suffered different injuries, at different levels of severity, with different medical histories and economic circumstances, courts may find that individual questions outweigh common ones

Ricciardi MR, McQueen T, Milella M, Edwards K, Kaldjian E, Sebolt-Leopold J, Konopleva M, Andreeff M

10.1152/ajprenal.00729.2010 170