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5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible persons [ see Warnings and Precautions (5.16)]

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Melatonin also reduces TXNIP, which leads to the suppression of ROS and NLRP3 (122)

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These particular beneficial effects, i.e., the activation of collateral pathways, should occur along with the activated molecular pathways (Tkalevi et al., 2007