Have known allergies to any ingredient in the formulation
Though settling isnt uncommon for powder supplements, its still at least a little annoying
Vitamin B12 is vital for DNA synthesis and methylation reactions (like DNA methylation), which impact gene expression, cellular function, and overall health

Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial - The Lancet, Diabetes & Endocrinology Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss - Diabetes, Obesity & Metabolism Once-Weekly Semaglutide in Adults with Overweight or Obesity - The New England Journal of Medicine Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity - Diabetes, Obesity & Metabolism Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus - Journal of Clinical Medicine Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss - JAMA

This is concerning, especially for older adults, because of the increased risk of falls and frailty
This isnt a technicality or an overly cautious disclaimer