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According to FDA prescribing information, gastrointestinal adverse effects occur in a substantial proportion of patients, particularly during dose initiation and escalation

Activation of the GLP-1 receptor (GLP-1R) by GLP-1 stimulates insulin release and inhibits glucagon secretion in a glucose-dependent manner ( 4 )

2- Altered Pain Modulation in the Central Nervous System: GLP-1 receptor signaling interacts with brain regions involved in pain modulation, such as the hypothalamus, amygdala, and periaqueductal gray matter

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This can depend on various factors, including your starting weight and how closely you adhere to the nutrition plan