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Typical protocols involve 2-4 sprays per nostril, 2-3 times daily, depending on your concentration and target dose

Selected Research References Seiwerth S, Sikiric P, Rucman R, et al

Journal of molecular medicine (Berlin, Germany) , 95 (3), 323-333

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However, if you experience severe diarrhea, vomiting, constipation, or any signs of an allergic reaction, please consult your doctor

Data availability The MIMIC-III data analyzed in this paper are publicly available through PhysioNet ( Mayo Clinic and Quebec CHD data are not publicly accessible due to restricted user agreement