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10.1016/j.metabol.2013.09.009 Metabolism Summary Keywords T2DM (type 2 diabetes), GLP-1, -cell, PARP-1, ABCA1 Citation Li R, Sun X, Li P, Li W, Zhao L, Zhu L and Zhu S (2021) GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic -Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux

Elevation of homocysteine arises from reduced activity of methionine synthase, a vitamin B 12 -dependent enzyme, however, this does not increase GSH biosynthesis

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Neuroprotection and Repair Alzheimers and dementia research: Dihexa was developed as a potential therapy for neurodegenerative diseases, aiming to restore connectivity lost in conditions like Alzheimers

These predispositions do not determine medication response, but may help provide context for why some patients experience stronger metabolic improvements than others

This further step in carnitine traffic can be possible if a nuclear isoform of CAT exists for regenerating acetyl-CoA from acetylcarnitine