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Hepatic lipotoxicity creates a pro-inflammatory environment that makes the liver highly susceptible to simultaneous insults, including mitochondrial dysfunction (generating oxidative stress), endoplasmic reticulum stress (Miller et al., 2025

In short, the difference between oral supplementation and injection is that an injection will provide a higher dose of B12 at regular intervals, whilst oral supplements have a lower dosage and can be taken every day

To further explore how gene expression differences may be related to sphingolipid differences, we selected the genes annotated to be involved in sphingolipid metabolism (Supplementary Fig

A reducing SDS-PAGE gel of the complex produced three bands, each consistent with the masses expected for the individual components

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