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are co-inventors of a patent application related to this work

However, we discovered remarkable changes in GLP-1 sequence and function, which we propose are the result of an unusual evolutionary trajectory of this important gene

These changes reduce the risk of metabolic syndrome, characterized by abdominal obesity, hypertension, insulin resistance, and dyslipidemia

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In addition, a crystal structure of the inactive full-length GLP-1R bound by an extracellular antibody, in the absence of a peptide ligand, was recently reported (Wu et al., 2020)

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