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A liquid pharmaceutical composition consisting of a) 3.2 mg/ml semaglutide, optionally b) no more than 0.1 %(w/w) phenol, c) above 6.4 mg/ml sodium chloride, d) buffer, e) at least 60% water, optionally g) one or more agents for adjusting pH, such as HCI, NaOH, or acetate, and said composition optionally has a pH of 6-10 such as 7-8

References Deanfield, John et al., Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial, The Lancet, Published on October 22, 2025, DOI: 10.1016/S0140-6736(25)01375-3 Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT), ClinicalTrials.gov ID NCT03574597,

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B12 supplements may also improve mood and reduce symptoms of depression, as well as improve skin and hair health by promoting cell growth and repair

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One known inhibitor of CROT is malonyl-CoA, which inhibits CROT non-linearly