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Yes, other medications can potentially interfere with semaglutide's effectiveness in promoting weight loss

Items like breakfast cereals, white bread, white rice, and regular pasta are simple carbohydrates, which means theyre broken down very quickly into sugar and cause your blood glucose to spike (as opposed to complex carbohydrates, which take longer and offer a slower, smoother rise in glucose)

GLP-1 (Glucagon-like peptide-1) is a naturally occurring hormone in your body that targets areas of the brain involved in appetite regulation

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Saxenda users should also keep an eye on their mental health due to the aforementioned neuropsychiatric risks

Research shows that combining higher protein intake with resistance exercise preserves lean mass and improves body composition during caloric deficit, and a 2025 systematic review found that exercise interventions alongside GLP-1 medications produced better outcomes for body composition than medication alone