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Thus, regulation of mitophagy may be a valuable therapeutic option that targets the elimination of dysfunctional mitochondria while still providing sufficient energy to mitigate cellular damage, restore protein translation, and ultimately restore homeostasis ( FIGURE 1 3 Overview of mitophagy Mitophagy is a mitochondria-specific form of autophagy that selectively degrades damaged mitochondria through receptors (Figure 2)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Eisenstein A., Hilliard B.K., Pope S.D., Zhang C., Taskar P., Waizman D.A., Israni-Winger K., Tian H., Luan H.H., Wang A

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These free radicals can be anything from UV exposure, everyday stress, alcohol, and more