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Although the mechanisms of drug resistance for ADCs have not been determined, research has shown that down-regulation of target antigen, reduction of internalization of ADCs and efflux of the active payload are possible causes

whether that translates to meaningful follicle perfusion in a topical preparation on people is undocumented

While hydroquinone was once an OTC option, the FDA has reined in the controversial benzene derivative, making it prescription-only in the United States as of September 2020

The researchers emphasized the need for larger, longer-term trials

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