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In this guide, we explain what these peptides are, what the science says so far, the risks you should know about, and what changed with the FDA in 2026

A Consensus Report of the American Diabetes Association

Peripheral Edema Insulin, including TOUJEO, may cause sodium retention and edema, particularly if previously poor metabolic control was improved by intensified insulin therapy

IGF-1 LR3 Results: What to Expect by Week IGF-1 LR3 results week by week: pumps, recovery, lean mass, and what before-and-after photos really show

Tirzepatide is also the active ingredient in Mounjaro, which is approved for type 2 diabetes

Both work against your body in some way