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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis (Iorga et al., 2017)

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Lancet Haematol 10 , e272e283 (2023)

The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination

Early-stage research suggests IGF-1 signaling may contribute to regeneration processes following muscular stress or injury, though human clinical evidence remains limited

Simultaneously, Ipamorelin binds to ghrelin receptors (GHS-R1a) on the same cells, providing more boost for GH release through a paired pathway