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Based on analyses of available crystal structures a tentative model for 23 (HA08) binding to IRAP was created in 2016 by applying MD simulations and calculating associated binding free energies by the linear interaction energy (LIE) method

The inflammatory cells express melanocortin receptors

Data sources: The Cochrane Library, MEDLINE, EMBASE.com, Science Citation Index, Google search and the China Biological Medicine Database to June 2012

Acquired prolactin deficiency in patients with disorders of the hypothalamic-pituitary axis

J Nat Prod, 2009

Patients with hypothalamopituitary disconnection showed complete blockade of the GHRP-6 response, confirming the importance of the hypothalamic pathway