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For subcutaneous injections, the abdominal site is preferred for most peptides due to the consistent subcutaneous fat layer thickness, proximity to the gut-associated lymphoid tissue (relevant for some anti-inflammatory peptides), and the practical convenience of self-administration in research settings

In a randomized placebo-controlled phase IIA trial of patients with prior OHE, VE303 was well tolerated and showed a trend toward improved PHES [152]

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