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Subjects with obesity: significantly higher NNMT activity in adipose tissue and liver

Available over-the-counter or on prescription Folate treatment : If folate deficiency is also present, this should be treated alongside B12 (not before), as treating folate deficiency alone can worsen neurological symptoms in B12 deficiency [4] Nail-specific care during treatment: Whilst nutritional repletion addresses the root cause, supportive nail care can minimise further damage: Keep nails trimmed short to reduce breakage Avoid harsh chemicals and prolonged water exposure Use moisturiser on nails and cuticles Wear protective gloves for household tasks Avoid nail polish removers containing acetone Monitoring response : Your GP will arrange follow-up blood tests to confirm improvement

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Biochemistry, 1970, 9(23): 4486-4492

Some may experience the benefits of their treatment very shortly and some may take weeks or months of treatment to experience the full effects of the treatment and an overall improved quality of life