However, direct head-to-head trials are needed to confirm these findings across diverse clinical settings
S.Fong-McMasterC.Cuperlovic-CulfM.et al (2024)
30 We are unable to determine through this study if improvement in psoriasis is due to mechanisms directly related to GLP-1RAs or through improved blood glucose management and weight loss
Orforglipron is an investigational, small-molecule, non-peptide GLP-1 receptor agonist taken orally once daily
Objective measurements (EEG, cardiovascular, and respiratory parameters) and subjective ratings (visual analog scales, awakening times) showed, assessed by Mann-Whitney U test, a normalization of severely disturbed sleep to normal sleep patterns
We will examine in detail the activation of immunosuppressive STAT3 signaling induced by the insulin/IGF-1 pathway