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Nature 544, 372376

(2008) 79:S1920

This strategy has been exploited in the long-acting GLP-1RA semaglutide (Novo Nordisk), for instance, which was approved for treatment of T2DM in 2017, and for treatment of obesity in 2021, and has since then become the most prescribed GLP-1RA 92

This is important as the lining prevents toxins and bacteria from escaping from the gut