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Avoid foods high in saturated fats, trans fats, and cholesterol, as these can increase the risk of heart disease

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Enhancing cGMP signaling can promote the recruitment of brown adipocytes, making it a potential target for anti-obesity therapies that increase energy expenditure in overweight individuals (Hoffmann et al., 2016

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Discontinue phentermine and topiramate extended-release capsules in patients who experience suicidal thoughts or behaviors [see Warnings and Precautions (5.9)]