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doi: 10.1016/j.nbd.2019.104644
The ChEMBL drug registry records tirzepatide at maximum phase 4 (approved), first approval 2022, parenteral, with a first-in-class GIP-agonist designation and a boxed-warning flag
During acute illness or dehydration, metformin should be temporarily stopped (follow 'sick day rules') and restarted when eating and drinking normally
Neuroplasticity driven by HGF/c-Met signaling includes upregulation of brain-derived neurotrophic factor (BDNF), activation of postsynaptic density protein-95 (PSD-95), and increased expression of GluN2B-containing NMDA receptors
1 Excess weightis also a risk factor for vitamin B 12 deficiency
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