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Alpelisib plus fulvestrant in PIK3CA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label, non-comparative study

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Being a relatively newer class of drug with numerous benefits, several national and international guidelines are working towards addressing clinical questions pertaining to the optimal use of GLP-1 RAs for the management of diabetes

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doi:10.1016/j.otc.2019.09.010 Gupta RJ, Kademani D, Liu SY

Although this amide hydrogen appears to make a hydrogen bond within the alpha-helix in the nGLP-1R-bound crystal structure, the adjacent side chains N-terminal of this H-bond, Glu24 and Lys27, make ionic interactions with the receptor [9]