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2 Propensity score matching likely isnt adequately accounting for difference in baseline diabetes severity, especially since the commentators point to a high degree of missing HbA1c values and not including other diabetes complications like nephropathy, neuropathy and peripheral vascular disease

The inter-individual variability was larger in the urinary than the salivary cortisol levels, which could be due to metabolic differences between individuals since urinary cortisol is metabolized before excretion 1,4

Other important safety considerations include hypoglycemia risk when combined with insulin or sulfonylureas, suicidal ideation (monitor for mood changes), and contraindication during pregnancy

Prioritise good sleep hygiene, aiming for 79 hours of quality sleep nightly

But, sometimes, a lot of upper GI bleeding can cause hematochezia

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